DIRECTOR:

Dr. Gustavo A. Appignanesi (Inv. Principal CONICET / Prof. Titular c/exc. Depto. Química, UNS)

This email address is being protected from spambots. You need JavaScript enabled to view it.

 
INTEGRANTES DEL EQUIPO DE INVESTIGACION: (Group members)

 

  1. Investigadores CONICET: (Researchers)
    Dr. J. Ariel Rodríguez Fris (Inv. Adj.),
    Dr. Laureano Alarcón (Inv. Adj.),
    Dra. Marcela Morini (Inv. Adj.),
    Dra. M. Belén Sierra (Inv. Adj.)

    Dr. Sebastian Accordino (Inv. Asist.)

 

  1. Becarios de CONICET: (Research fellows / PhD. candidates)
    Lic. Joan Manuel Montes de Oca

    Lic. Cintia Menendez

    Lic. Alejandro Verde

     

 Temas de trabajo: (Research interests)

 -   Relajación de sistemas vítreos. (Relaxation of glassy systems).

 -   Agua pura, sobreenfriada, de hidratación y nano-confinada. Agua biológica (proteínas, membranas). (Pure, supercooled, hydration and nano-confined water. Biological water (proteins, membranes)).

 -  Autoensamble en medio acuoso con interés en ciencia de materiales y biología. Hidrofobicidad e interacciones no-covalentes. (Self-assembly in aqueous media with interest in materials science and biology. Hydrophobicity and non-covalent interactions).

 -  Interacciones proteína-proteína y diseño de drogas. (Protein-protein interactions and drug design).

 -  Membranas biológicas. Interacciones con ligandos y efectores. (Biological membranes. Interactions with ligands and effectors).

 Publicaciones seleccionadas: (Selected publications)

 “Democratic particle motion for meta-basin transitions in simple glass-formers”, G.A. Appignanesi, J.A.Rodríguez Fris, R.A. Montani and W. Kob, Phys. Rev. Lett. 96, 057801 (2006).

 “Reproducibility of Dynamical Heterogeneities and Metabasin Dynamics in Glass Forming Liquids: The Influence of Structure on Dynamics”, G.A. Appignanesi, J.A.Rodríguez Fris and M.A. Frechero, Phys. Rev. Lett. 96, 237803 (2006).

“Metabasin dynamics and local structure in supercooled water”, J.A. Rodríguez Fris, G.A. Appignanesi, E. La Nave and F. Sciortino, Phys.Rev. E 75, 041501 (2007).

 “Evidence of a two-state picture for supercooled water and its connections with glassy dynamics”, G. A. Appignanesi, J. A. Rodríguez Firs and F. Sciortino, Eur. Phys. J. E 29, 305-310 (2009).

 “Experimental verification of rapid, sporadic particle motions by direct imaging of glassy colloidal systems”, J. A. Rodríguez Fris, G. A. Appignanesi and E. R. Weeks, Phys. Rev. Lett. 107, 065704 (2011).

 “Structure and orientation of water molecules at model hydrophobic surfaces with curvature: from graphene sheets to carbon nanotubes and fullerenes”, L. M. Alarcón, D. C. Malaspina, E. P. Schulz, M. A. Frechero and G. A. Appignanesi, Chem. Phys. 388, 47-56 (2011).

 “Behavior of water in contact with model hydrophobic cavities and tunnels and carbon nanotubes”, E.P. Schulz, L.M. Alarcón and G.A. Appignanesi, Eur. Phys. J. E 34, 114 (2011).

“Wrapping mimicking in drug-like small molecules disruptive of protein-protein interfaces”, Sebastián R. Accordino, Marcela A. Morini, María Belén Sierra, J. Ariel Rodríguez Fris, Gustavo A. Appignanesi and Ariel Fernández, Proteins: Struct., Funct. & Bioinf. 80, 1755-1765 (2012).

 “Productive induced metastability in allosteric modulation of kinase function”, J. M. Montes de Oca Joan, J. A. Rodriguez Fris Ariel, G. A. Appignanesi and A. Fernández Ariel, FEBS J 281, 3079 (2014).

““Chameleonic” backbone hydrogen bonds in protein binding and as drug targets”, C.A. Menéndez, S.R. Accordino, D.C. Gerbino, and G.A. Appignanesi, Eur. Phys. J. E 38, 107 (2015).

 “Hydrophilic behavior of graphene and graphene-based materials”, S. R. Accordino, J. M. Montes de Oca, J. A. Rodriguez Fris and G. A. Appignanesi, J. Chem. Phys. 143, 154704 (2015).

 “Water populations in restricted environments of lipid membrane interphases”, L.M. Alarcón, M.A. Frías, M.A. Morini, M.B. Sierra, G.A. Appignanesi and E.A. Disalvo, Eur. Phys. J. E 39, 94 (2016).

 “Hydrogen bond dynamic propensity studies for protein binding and drug design”, C.A. Menéndez, S.R. Accordino, D.C. Gerbino, G.A. Appignanesi, PLoS ONE 11, e0165767 (2016).

 “Studies on electrostatic interactions within model nano-confined aqueous environments of different chemical nature”, J. M. Montes de Oca, C. A. Menéndez, S. R. Accordino, D. C. Malaspina and G. A. Appignanesi, Eur. Phys. J. E 40, 78 (2017).

 “Design, synthesis and biological evaluation of 1,3-dihydroxyxanthone derivatives: Effective agents against acetylcholinesterase”, C. A. Menéndez, B. Biscussi, S. Accordino, A. P. Murray, D. C. Gerbino and G. A. Appignanesi, Bioorg. Chem. 75, 201–209 (2017).

 

 

 

 

Go to top